Check the manual, but 2x16GB is almost always fine.

Yes, unless you’re on a very old platform or a weird OEM board. Most modern motherboards support 2x16GB without issue.

The real question isn’t “does it support 2x16GB?” — it’s “will it run at the speed you want?” For that, look up the motherboard’s Qualified Vendor List (QVL) for 2x16GB kits. But that list is never exhaustive. If the kit you want isn’t on it, it’ll almost certainly still work, just maybe not at the rated XMP/EXPO speed.

The days of needing 4x8GB because the board couldn’t handle 16GB per slot are mostly over. That was a DDR3-era limitation. With DDR4 and DDR5, you’re fine unless you’re using some obscure chipset from 2012.

One exception: some older Intel H-series or B-series chipsets (like H310) limited max memory per slot to 8GB. But you’d know if you had that — you’d be buying used or building a budget office PC from 2017.

So check your motherboard’s spec sheet for “Max Memory Capacity per Slot” if you’re paranoid. Otherwise, just buy the 2x16GB kit.