ECC memory is overkill for Premiere Pro.

No, it won’t make a meaningful difference.

Corrupted frames during long renders in Premiere Pro almost never come from memory errors. They come from overheating CPUs, buggy GPU drivers, insufficient power, or dodgy storage. ECC memory fixes bit flips in RAM — a problem that’s extremely rare in a desktop workstation doing video work. You’d need to be running renders for weeks straight at 100% memory utilization for it to matter.

I’ve seen plenty of renders fail. Every single time it was a driver crash, a hard drive dying, or a thermal throttle, not a cosmic ray hitting a DIMM. If you’re paranoid about stability, spend the money on a better PSU, more RAM (non-ECC is fine), or a proper cooling system. Those will actually prevent the crashes that cause corrupted frames.

Future You is better off with a fast SSD and a reliable GPU.