Thick desk mats can lift your mouse sensor, but it's rare.

Yes, it can happen, but only with really thick mats (5mm+) and aggressive movements. Most tall gaming mice have sensors deep enough that a standard 2-3mm mat won’t cause lift-off. If you’re slamming the mouse around, sure—the fabric compresses unevenly and the sensor loses contact. Keep it under 3mm and you’re fine.