Yes, but vent the cooler.

Yes, you can use dry ice in a Yeti cooler, but you have to leave the drain plug open or crack the lid slightly. The key issue is pressure buildup—dry ice sublimates into CO2 gas, and a sealed Yeti can bulge or even burst.

Place the dry ice at the bottom, then regular ice on top to slow sublimation. Handle dry ice with thick gloves or tongs; don’t let it touch your skin. Also, don’t put it directly against the plastic walls—Yeti’s rotomolded construction is tough, but direct contact with -109°F can stress the liner. Use a piece of cardboard or a towel as a buffer.

Ventilation is the only real precaution. As long as the cooler isn’t airtight, you’re fine.

Just don’t seal it tight and you’ll be good.