Your vertical mouse doesn't need a special mousepad.

No, you don’t need a special mousepad for a vertical mouse.

Wrist fatigue is mostly about the angle of your hand. That’s the whole point of a vertical mouse — it rotates your wrist into a more natural handshake position. The mousepad itself is secondary to that.

A standard cloth mousepad works fine. The main thing you want is smooth movement and maybe a little cushioning for your palm if you rest it. A gel wrist rest can actually hurt you here — if you rest your wrist while mousing, vertical or not, you compress the carpal tunnel. You want to float your arm, not anchor your wrist.

Some companies sell “vertical mouse ergonomic pads” with angled slopes and cutouts. I’ve tried a couple. They mostly just slide around and don’t do anything a flat pad wouldn’t. The vertical mouse already gives you the angle.

Save your money for a better desk height or a good chair. That’s where the real ergonomic difference lives.